✦ LIBER ✦
Specific cleavage of chicken αA-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I
✍ Scribed by I. B. Bronstein; I. I. Gromova; S. V. Razin
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 801 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0300-8177
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✦ Synopsis
Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken alpha A-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.