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Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

โœ Scribed by Hermel, E; Gafni, J; Propp, S S; Leavitt, B R; Wellington, C L; Young, J E; Hackam, A S; Logvinova, A V; Peel, A L; Chen, S F


Book ID
110016679
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
794 KB
Volume
11
Category
Article
ISSN
1350-9047

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## Abstract Apoptosis, a cell death mechanism regulated by Bclโ€2 family members, has been proposed as one of the mechanisms leading to neuronal loss in Huntington's disease (HD). Here we examined the regulation of Bclโ€2 family proteins in three different mouse models of HD with exon 1 mutant huntin