## Abstract ## Objective Rheumatoid arthritis (RA) is characterized by progressive joint destruction. The aim of this study was to clarify the relevance of RA synovial fibroblasts (RASFs) and fibroblast growth factor 2 (FGFβ2), which is produced abundantly by RASFs, to the osteoclastogenesis and b
Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor
β Scribed by M. Vigny; M. P. Ollier-Hartmann; M. Lavigne; N. Fayein; J. C. Jeanny; M. Laurent; Y. Courtois
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 997 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of
## Abstract Interaction of basic fibroblast growth factor (bFGF) with heparin/heparan sulfate proteoglycans protects the growth factor against proteolytic degradation and is essential for its cellular activity. Although the structural requirements of heparin and heparan sulfate for the highβaffinit