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Specific assay methods for droperidol and fentanyl citrate in a pharmaceutical combination

✍ Scribed by Casimir A. Janicki; Ronald J. Brenner; Barbara E. Schwartz

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
542 KB
Volume
57
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

In acid solution, droperidol, 1-{ ~-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl} -2-benzimidazolinone, is decomposed to form 4'-fluoro-4-(4oxopiperidino) butyrophenone and 2-benzimidazolinone. Fentanyl, N-( 1-phenethyl-4-piperidyl)propionanilide, is decomposed in acid solution to form 4-anilino-1-(2-phenylethy1)piperidine. A procedure to assay droperidol in the presence of its hydrolysis products, fentanyl, and its hydrolysis product is given. Droperidol is analyzed by its UV absorption after being separated from interfering products. A procedure to assay fentanyl in the presence of its hydrolysis products, droperidol, and its hydrolysis products is given. Droperidol and 4-anilino-1-(2-phenylethy1)piperidine are separated from fentanyl through the formation of a reineckate derivative and fentanyl is subsequently determined by a methyl orange procedure.

Data are presented to show the accuracy and precision of the methods.

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