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Specific and stable CTL tolerance induced by veto mechanism

✍ Scribed by Donald V. Cramer


Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
108 KB
Volume
7
Category
Article
ISSN
0167-5699

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Donor-specific tolerance to heart allograft was induced in adult Lewis rats by pregraft donorspecific blood transfusion (DST). We previously showed that this tolerant state is characterized by a dramatic inhibition of T cell and macrophage activation. In addition, tolerant animals could not mount an