✦ LIBER ✦

Specific and nonspecific macromolecule–drug conjugates for the improvement of cancer chemotherapy

✍ Scribed by Ester Hurwitz

Publisher: Wiley (John Wiley & Sons)
Year: 1983
Tongue: English
Weight: 566 KB
Volume: 22
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360220168

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✦ Synopsis

Antineoplastic drugs such as daunomycin, adriamycin, methotrexate, 5-fluorouridine, cytosine arabinoside, and platinate were bound to antibodies directly or via a polymeric bridge. The drug antibody conjugates retained most oftheir drug and antibody activities when tested in oitro. Daunomycin-antibody conjugates were shown to penetrate tumor cells in the conjugated form. In animals, daunomycin-antibody conjugates were a t least as effective chemotherapeutically as the corresponding free drugs and considerably less toxic. In some tumor systems, the daunomycin-antibody conjugates represented an improvement over the free drug. This improvement was restricted in some tumors to a particular injection route of'the tumor and the treatment.

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