Species differences in substrate specifi
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Yoshihiko Maehara; Yoshihisa Sakaguchi; Tetsuya Kusumoto; Hiroki Kusumoto; Keizo
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Article
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1989
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John Wiley and Sons
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English
β 280 KB
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To compare the activity of pyrimidine nucleoside phosphorylase (PNP), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), we used uridine (Urd), deoxyuridine (dUrd), and thymidine (dThd) as substrates and human, rat, and mouse neoplastic and normal tissues. As PNP activity was higher in t