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Species-specific analysis of protein sequence motifs using mutual information

✍ Scribed by Jan Hummel; Nima Keshvari; Wolfram Weckwerth; Joachim Selbig


Book ID
114999935
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
376 KB
Volume
6
Category
Article
ISSN
1471-2105

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We have studied the relationship between amino acid sequence and substrate specificity in a DNA glycosylase family by characterizing experimentally the specificity of four new members of the family. We show that principal component analysis (PCA) of the sequence family correctly predicts the substra