Species differences in cAMP production and contractile response induced by β-adrenoceptor subtypes in urinary bladder smooth muscle
✍ Scribed by Takashi Morita; Masao Ando; Kazunori Kihara; Hiroyuki Oshima
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 353 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0733-2467
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✦ Synopsis
The contractile activity of urinary bladder smooth muscle has been shown to be inhibited by P-adrenoceptor agonists. P-Adrenoceptor subtypes in the rabbit, canine, and human urinary bladder smooth muscles were studied by measuring changes in contractile forces and in intracellular cAMP concentrations on administration of P-adrenoceptor agonists. In the rabbit bladder, only P,-receptors may have functional roles in the detrusor muscle, while both PIand @,-receptors may have functional roles in the detrusor muscles of the canine bladder. Only P,-receptors may have functional roles in the human detrusor muscles, similar to the rabbit detrusor muscles. Thus, species differences may exist in P-adrenoceptor subtypes in smooth muscles of urinary bladder. C