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Species Difference in Intestinal Absorption Mechanism of Etoposide and Digoxin between Cynomolgus Monkey and Rat

✍ Scribed by T. Nishimura; Y. Kato; N. Amano; M. Ono; Y. Kubo; Y. Kimura; H. Fujita; A. Tsuji


Book ID
106493497
Publisher
Springer US
Year
2008
Tongue
English
Weight
246 KB
Volume
25
Category
Article
ISSN
0724-8741

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In order to elucidate the causes of the species differences in the oral bioavailability (BA) between cynomolgus monkeys and humans, the contributions of first-pass metabolism and intestinal absorption were investigated. Typical substrates of cytochrome P450 enzymes, UDP-glucuronosyltransferase enzym