The species differences of intestinal dr
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Masayuki Takahashi; Takuo Washio; Norio Suzuki; Katsuhiro Igeta; Shinji Yamashit
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Article
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2009
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John Wiley and Sons
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English
β 200 KB
In order to elucidate the causes of the species differences in the oral bioavailability (BA) between cynomolgus monkeys and humans, the contributions of first-pass metabolism and intestinal absorption were investigated. Typical substrates of cytochrome P450 enzymes, UDP-glucuronosyltransferase enzym