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Species and Strain Differences in the Hepatic Cytochrome P450-Mediated Biotransformation of 1,4-Dichlorobenzene

✍ Scribed by A.M. Hissink; M.J. Oudshoorn; B. Van Ommen; P.J. Van Bladeren


Book ID
112266418
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
143 KB
Volume
145
Category
Article
ISSN
0041-008X

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Species differences in ciprofibrate indu
✍ Makowska, Janet M. ;Gibson, G. Gordon ;Banner, Frank W. πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 849 KB

Six species (CD-1 mouse, Fischer 344 rat, Syrian golden hamster, Duncan-Hartley guinea pig, half-lop rabbit and marmoset monkey) were treated orally with ciprofibrate, a potent oxyisobutyrate hypolipidaemic drug for 14 days. A dosedependent liver enlargement was observed in the mouse and rat and at