Speciation of Arsenic Compounds in the Urine of Rats Orally Exposed to Dimethylarsinic Acid Ion Chromatography with ICP–MS as an Element-Selective Detector
✍ Scribed by Yoshinori Inoue; Yukiko Date; Kaoru Yoshida; Hua Chen; Ginji Endo
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 355 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
A combined ion chromatography (IC) with inductively coupled plasma mass spectrometry (ICP-MS) system as an element-selective detector has been used for the determination of arsenic compounds. Seven arsenic compounds were separated by cation-exchange chromatography. Subsequently, the separated arsenic compounds were directly introduced into the ICP-MS and were detected at m/z = 75. Detection limits for the seven arsenic compounds ranged from 0.8 to 3.8 pg AsA. The IC-ICP-MS system was applied to the determination of arsenic compounds in the urine of dimethylarsinic acid (DMAA)exposed rats. DMAA was the most abundant arsenic compound detected. Arsenous acid, monomethylarsonic acid and trimethylarsine oxide were also detected.