𝔖 Bobbio Scriptorium
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Special issue: Mechanisms of carrier-mediated intracellular delivery of therapeutics

✍ Scribed by G. Divita; F. Heitz

Book ID
116274228
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
44 KB
Volume
1758
Category
Article
ISSN
0005-2736

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## Abstract ## Background Polyethylenimine (PEI) polyplexes mediate efficient gene transfer only at high +/− charge ratios at which free noncomplexed PEI is present. The excess of PEI gives polyplexes a positive surface charge that plays a role in polyplex binding on the cell membrane. Although po