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Spatially localized 31P NMR measurements of longitudinal relaxation rates in the canine myocardium

✍ Scribed by D. P. Rath; A. M. Abduljalil; P.-M. L. Robitaille

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
414 KB
Volume
29
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

FLAX‐ISIS spatial localization was combined with inversion recovery to enable the measurement of spatially localized T~1~ values. This approach was applied to the transmural determination of creatine phosphate longitudinal relaxation times in the canine myocardium. By examining five voxels spanning the left myocardial wall, we observed that transmural T~1~ values for creatine phosphate ranged from 3.61 = 0.20 in the endocardium to 4.00 ± 0.20 in the epicardium at 4.7 Tesla. As such, the canine myocardium exhibits no transmural variation in the T~1~ values of creatine phosphate. This simple approach can be extended to enable the in vivo measurement of transmural enzymatic rates.

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