Spatial interrelationship of pHa, PACO2 and respiratory VT in chemodenervated decerebrate cats
✍ Scribed by Herbert L. Borison; Lawrence E. McCarthy; Goeffrey C. Lamb
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 891 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0010-4809
No coin nor oath required. For personal study only.
✦ Synopsis
Observations on P,CO,, pH,,, and V., are made in decerebrate cats in which HCI (0.5N) or NaHCO,, ( l.ON) is infused intravenously to shift pH,, over the range of 6.95 to 7.64 while P,CO, is controlled over the range of 18 to 54 Torr. Analysis of the data is computerized to determine the equation of a plane that defines the separate influences of log P,COp and pH,, upon the resultant V.,. level from three noncolinear steady-state data points. Additionally. the computer is programmed to graph the plane in three dimensions. Linearity of the IpH;,-1V.r response is demonstrated by superposition of planes following stepwise shifts in pH,,. The average fractional contributions of CO, and hydrogen ion to V.,. with the vagus and carotid sinus nerves intact are 73 and 27%, respectively. No significant change in response fractions occurs after carotid chemodenervation and/or vagotomy despite significant changes in response gains. It is concluded that CO, and hydrogen ion in the arterial blood act centrally as independent and additive feedback signals to the V, controller over the entire physiological range of chemorespiratory regulation.