Spatial distribution of mitosis, apoptosis and small blood vessels in malignant diffuse follicular-center-cell lymphomas: A nearest-neighbor analysis
✍ Scribed by Rainer Kraft; Paolo Barbini; Lorenzo Leoncini; Maria T. Del Vecchio; Tiziana Megha; Chiara Minacci; Donatella Spina; Maria R. Massai; Piero Tosi; Jean A. Laissue; Hans Cottier
- Book ID
- 102868104
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 757 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
To better comprehend the relationships between cell birth and cell death in neoplastic disorders, the topography of these events needs to be considered. We applied a computerized nearest-neighbor analysis to malignant, diffuse follicular-centercell lymphomas in order to examine the spatial distribution of pyknotic (apoptotic) cells/bodies (A) and mitotic figures (M) in relation to capillaries (C) and venules 0. The results revealed a complex dispersion pattern, with significant aggregations of A and M, in addition to an even greater random distribution component. The greatest clustering displayed by A was around capillaries ( A X , 42% reduction of object frequency between the first and second distance class), followed by &A (33%), A-V (24%) and A-M (I 2v0). Additional values for mitotic figures were: M-M (45Oh), M-V (33%) and M-C (22%). These findings may reflect the relative importance of inherent properties of the neoplastic and host factors, respectively. in the regulation of cell birth and cell death rates.