Spasmolytic activities of Hydrastis canadensis L. on rat uterus and guinea-pig trachea
✍ Scribed by M. F. Cometa; H. Abdel-Haq; M. Palmery
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 257 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
This study describes the reversible smooth muscle relaxant activities of an alcoholic extract of Hydrastis canadensis L. on rat uterine preparations and guinea-pig trachea. In the non-pregnant rat uterus the extract inhibited the amplitude of rhythmic spontaneous contractions (IC 50 10 AE 3.07 mg/mL) and of contractions induced by 5HT (IC 50 19.9 AE 3.87 mg/mL), oxytocin (IC 50 10.5 AE 0.37 mg/mL) and acetylcholine (IC 50 9.95 AE 1.77 mg/mL). The extract also relaxed carbachol precontracted guinea-pig trachea (EC 50 1.6 AE 0.943 mg/mL). Timolol partially antagonized this effect on trachea strips (EC 50 5.28 AE 0.653 mg/ mL) suggesting that the extract produces relaxation by b-adrenoceptor-dependent and -independent mechanisms.