SPARC, a matricellular protein: at the crossroads of cell–matrix
✍ Scribed by Rolf A. Brekken; E.Helene Sage
- Book ID
- 117640200
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 433 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0945-053X
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Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that inhibits cellular adhesion and proliferation. In this study, we report the detection of SPARC in the interphase nuclei of embryonic chicken cells in vivo. Differential partitioning of SPARC was also noted in the cyt
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## Abstract The matricellular SPARC‐family member hevin (Sparc‐like 1/SPARCL‐1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. Based on sequence similarity, we hypothesized that proteolytic digestion of hevin would result in SPARC‐like fragm