Space-time clustering and bone tumours: Application of Knox's method to data from a population-based cancer registry
✍ Scribed by P. B. S. Silcocks; T. Murrells
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 357 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
The possibility of space-time clustering in osteosarcoma and (Clark, personal communication, 1986). The ICD codes re-Ewing's tumour was studied in a sample of 182 patients aged corded by the registry were then scrutinized by one of US under 25 years, drawn from a population-based cancer reg's-(P.B.S.) to ensure that only cases of osteosarcoma and Ewtry. No evidence of space-time clustering was found for either ing's turnour were included.
disease and this finding supports previous work in this field. Knox's method (1964) was used to detect space-time clustering. With this all possible pairs of cases are classified as be-Under experimental conditions a number of different viruses ing close/distant in space and close/distant in time, forming a have been shown to cause OSteOSarcOmaS and other malignant 2 x 2 contingency table. The number of pairs that are close in turnours of connective tissue. Among such agents are Row both space and time is compared with the number expected on Sarcoma the basis of the usual formula utilizing the marginal totals. sarcoma viruses ( R O W t't a / . , 1912; DiamandoPouh 1973; The variances of the observed values were found by Man-Fujinaga et al., 1970; Soehner and Dmochowsh, 1969). It tel's method (1967) using the algorithm given by Pike and