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Sp1-decoy oligodeoxynucleotide inhibits high glucose-induced mesangial cell proliferation

✍ Scribed by Young-Mi Chae; Kwan-Kyu Park; Junji Magae; In-Seon Lee; Cheorl-Ho Kim; Hyun-Chul Kim; SaHyun Hong; Jin-Gu Lee; In-Jang Choi; Hyun-Soo Kim; Kwan-Sik Min; In-Kyu Lee; Young-Chae Chang

Book ID: 116288531
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 218 KB
Volume: 319
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.05.025

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## Abstract Transcription factor Sp‐1 is an important fibrogenic factor that is involved in the pathogenesis of diabetic nephropathy. In this study, we examined the effect of Sp1 decoy oligodeoxynucleotides (ODNs) on the extracellular matrix (ECM) gene expression in cultured rat mesangial cells (RM

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