Soy-derived Isoflavones Inhibit HeLa Cell Growth by Inducing Apoptosis
β Scribed by Jun-Xia Xiao; Guo-Qing Huang; Xin Geng; Hong-Wei Qiu
- Book ID
- 106508375
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 489 KB
- Volume
- 66
- Category
- Article
- ISSN
- 1573-9104
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We have designed and synthesized three novel compounds, 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-benzilidene-3-ethyl rhodanine (BTR-1), and have tested their chemotherapeutic properties. Our results showed that all three
## Abstract We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing __in vitro,__ and caused downregulation of NFβΞΊB and APE1/Refβ1. APE1/Refβ1 functions as a redox activator of transcription factors, including NFβΞΊB and HIFβ1