Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice

Paranodal axoglial junction is required

Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice

✍ Ayaka Suzuki; Tomiko Hoshi; Tomoko Ishibashi; Akiko Hayashi; Yoshihide Yamaguchi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 1 views

## Abstract In myelinated axons, voltage‐gated sodium channels specifically cluster at the nodes of Ranvier, while voltage‐gated potassium channels are located at the juxtaparanodes. These characteristic localizations are influenced by myelination. During development, Nav1.2 first appears in the pr