Glutathione (GSH) is important in antioxidant defense. A major determinant of the rate of GSH synthesis is the activity of the rate-limiting enzyme, ␥-glutamylcysteine synthetase (GCS). A heavy (HS) and light subunit (LS) make up GCS; oxidative stress regulates both transcriptionally. Cis-acting ele
Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat
✍ Scribed by T. C. Delgado; D. Pinheiro; M. Caldeira; M. M. C. A. Castro; C. F. G. C. Geraldes; P. López-Larrubia; S. Cerdán; J. G. Jones
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 216 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.1327
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This study was partially supported by grants UBACYT M055 (Universidad de Buenos Aires) and PICT 06-124 (Agencia Nacional de Promocio´n Cien-tı´fica y Tecnolo´gica).
The liver plays a central role in lipoprotein metabolism. In particular, very-low density lipoprotein (VLDL) is assembled in the hepatocytes and secreted into the blood circulation. The VLDL is then catabolized to low-density lipoprotein by lipoprotein lipase and hepatic triglyceride lipase. Obese s
## Abstract The association between a high‐fat diet and breast cancer risk is controversial. We hypothesized that the exposure of rats to a high‐fat diet __in utero__ __via__ the maternal diet would result in a greater risk of carcinogen‐induced mammary tumors than high‐fat diet exposure in postnat