Mechanism-based isocoumarin inhibitors f
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James C. Powers; Chih-Min Kam; Lakshmi Narasimhan; Joszef Oleksyszyn; Maria A. H
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Article
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1989
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John Wiley and Sons
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English
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Isocoumarins are potent mechanism-based heterocyclic irreversible inhibitors for a variety of serine proteases. Most serine proteases are inhibited by the general serine protease inhibitor 3,4-dichloroisocoumarin, whereas isocoumarins containing hydrophobic 7-acylamino groups are potent inhibitors f