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Sorafenib Suppresses Translation in Desmoid Tumors via Inhibition of mTOR Signaling

✍ Scribed by Rosenberg, Laura M.; Yoon, Charles H.; Bertagnolli, Monica M.; Cho, Nancy L.


Book ID
127164550
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
61 KB
Volume
219
Category
Article
ISSN
1072-7515

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## Abstract Oleanolic acid (OA), a pentacyclic triterpenoid exhibits potent anti‐tumor activity against many tumor cell lines. But the mechanisms through which OA inhibits osteosarcoma cells are not known. The mammalian target of rapamycin (mTOR) serves as a central regulator of cell growth, prolif