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Sorafenib reduces hepatic infiltrated regulatory T cells in hepatocellular carcinoma patients by suppressing TGF-beta signal

โœ Scribed by Quanrongzi Wang; Tongfu Yu; Yifeng Yuan; Haiwen Zhuang; Zhaojing Wang; Xisheng Liu; Min Feng


Book ID
118763399
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
326 KB
Volume
107
Category
Article
ISSN
0022-4790

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โœ Ingrid M.E. Desar; J. (Hans) F.M. Jacobs; Christina A. Hulsbergen-vandeKaa; Wim ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 335 KB ๐Ÿ‘ 2 views

## Abstract Tyrosine kinase inhibitors (TKIs) as sorafenib are known to reduce the number of immunosuppressive regulatory T cells (Tregs) in the peripheral blood and thereby shifting the immune balance to a more stimulating setting. The effect of sorafenib on intratumoural Tregs is unclear but impo