Thomas J
Sophisticated techniques detect obscure lymph node metastases in carcinoma of the breast
โ Scribed by Armando E. Giuliano; Pond R. Kelemen
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 85 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
โฆ Synopsis
As Cancer commemorates 50 years of continuous publication, this article is one of a series of summaries on the current status of some of the oncologic issues reported in the first volume in 1948.
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## Background: Axillary lymph node metastases (alnm) are the most important predictor of survival in patients with t1 breast carcinoma. due to a relatively low incidence of axillary metastasis in tumors < or = 2 cm, the role of axillary lymph node dissection for these patients has been questioned.
This study was undertaken to assess a multiple-marker RT-PCR and Southern blot assay for detection of metastases in frozen sections of sentinel lymph nodes from breast cancer patients. Sentinel lymphadenectomy was performed in 41 AJCC (American Joint Committee on Cancer) stage I-IIIA breast cancer p
## BACKGROUND. Thirty percent of lymph node negative patients with operable breast carcinoma experience disease recurrence within 10 years. Retrospective serial sectioning of axillary lymph nodes has revealed undetected metastases in 9 -30% of these patients. These occult metastases have been show