Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: Incidence and time course
✍ Scribed by Avila, Nilo A.; Shawker, Thomas H.; Roach, Paris; Bradford, Mary H.; Skarulis, Monica C.; Eastman, Richard
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 193 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0091-2751
No coin nor oath required. For personal study only.
✦ Synopsis
Purpose:
We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly.
Methods:
We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. group i (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. group ii (10 patients) was treated with ursodiol while receiving octreotide therapy.
Results:
Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). ursodiol reversed the gallbladder abnormalities in 7 of 10 patients.
Conclusions:
A majority of patients receiving octreotide develop gallbladder abnormalities. ursodiol appears to reverse the abnormalities in most cases.