Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro
Sonography: A useful tool to detect the mechanical causes of renal transplant dysfunction
β Scribed by Gottlieb, Ronald H.; Voci, Susan L.; Cholewinski, Scott P.; Hartley, Donna F.; Rubens, Deborah J.; Orloff, Mark S.; Bronsther, Oscar L.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 456 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0091-2751
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β¦ Synopsis
Purpose:
The purpose of this study was to evaluate the utility of sonography in distinguishing between mechanical and nonmechanical causes for renal transplant dysfunction.
Methods:
We reviewed all ultrasound examination reports (n = 286) for 63 consecutive patients who received 64 renal transplants. we assessed the sensitivity and specificity of different degrees of hydronephrosis (mild, moderate, or severe) in detecting urinary tract obstruction; different volumes of new or increasing peritransplant fluid in detecting urine leaks; different total volumes of peritransplant fluid in predicting significant compression of the transplant; and doppler vascular criteria for predicting arterial and venous occlusion.
Results:
All mechanical complications were detected (100% sensitivity) with specificities of 91.9% for ureteral obstruction (criterion, moderate hydronephrosis), 83.4% for urine leaks (criterion, any new fluid or any increase), 91.4% for fluid collections that compressed the transplant (criterion, > 100 ml), and 100% for vascular occlusion (criteria, no flow for arterial occlusion; no venous flow and reversal of arterial flow during diastole for venous occlusion).
Conclusions:
Sonography is very useful in distinguishing between mechanical and nonmechanical causes for renal transplant dysfunction. it has high sensitivity and acceptable specificity in this setting.
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