## Abstract A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of __GLI1__. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by __GLI1__ w
✦ LIBER ✦
Sonic hedgehog pathway—a potential target for pancreatic adenocarcinoma treatment
✍ Scribed by Elena Y. Rakhlin; David Rosow; Aram Hezel; Oliver Strobel; Mari Mino-Kenudson; Amy Stirman; Elaina Mikhailova; Carlos Fernandez del Castillo; Andrew Warshaw; Sarah Thayer
- Book ID
- 113677266
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 60 KB
- Volume
- 203
- Category
- Article
- ISSN
- 1072-7515
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## Abstract Pancreatic adenocarcinoma carries an ominous prognosis and has little effective treatment. Several studies have demonstrated that the potently antiapoptotic phosphatidyl inositol 3′‐kinase (PI3K)—protein kinase B/AKT pathway is active in pancreas cancer. A recent study identified an end