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Some species differences in fibrinolysis and blood coagulation

✍ Scribed by Mason, R. G. ;Read, M. S.

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 408 KB
Volume: 5
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820050109

No coin nor oath required. For personal study only.

✦ Synopsis

The plasminogen levels and the reactivities of plasmas in two commonly used blood coagulation tests have been compared for man and seven mammals. The plasmas of three nonhuman primates in general reacted as did human plasma in tests for plasminogen activation and in reactivity in the partial thromboplastin time test. The dog had the highest level of plasminogen, and the goat the lowest, of the eight species tested. Overall, the pig appeared to have the most reactive blood coagulation mechanism, clotting the fastest and lysing the slowest, while man's was among the least reactive in clotting and intermediate in lytic activity of those tested. Aside from the nonhuman primates, the calf's clotting and lytic mechanisms resembled those of man more nearly than did those of the other mammals tested. The influence of these species differences on selection of animals for in uzio evaluation of blood vascular prosthetic materials and devices is discussed.

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