In his prcsidcntinl address to thc Miyeiology Scction of thc British Association in 192.1, Dr. Dale rcvicwed tlic progress in chemothcrnpy to dntc, nnd discussed its future prospects. Quitc rcccntly, Fonrncnu (Prnctitioncr, 1930, 257) has suniniariscd the present position nnd lists in foiir groups thc drugs of undoiihtcd vnluc which linvc been introduccd into practice sincc snlvnrsiin and ncosnlvnrsan. They arc :- (I) Two dcriratives of pcntavalcnt arscnic, trypsnrsuuiidc nud stovnrsol.
(2) Innanicrnblc bisniiith dcrivntires, includini nictal, osidc, and salts, but not iucluding any truc orgnnolknriith dcrivntivc.
(3) Antimony dcrivntivcs, such as sodium nniinophcnylstibinntc.
(-I) hcriflnviuc and rivnnol ; also nicrcurocliromc and liesyl rcsorcinol.
Aniongst drugs which have not yct cstnblielicd their viiluc t,horouglily> hc mcntions Bnycr 205 and pliis-N arid had D. marked antipyretic nctiou in human fevers when adnhistcrcd in doves of 0.1 to 0.2 g.
Tlic recent rescarcli of tlic I. G. Farbcnindustric A.-G., Iio\wcr, nppcars from n pcrusal of their patent spccificntions t o ham been concerncd with derivatives of 8-nminoquinolinc, nnd S-nmino-G-mctholryqniuoline, nnd this firm has statcd (Arch. SchiB. Trop. Hyg., 1928, 42, 382) tliut plnsmoqiiinc basc is 8-diethylaminoiso-pcnt;ylnmino-6-mctIiosyqiiinolinc.
Only onc compound is clcscribcd in thcir pntcnts, wliicli ngrccs with this dcscription, nnmcly, S-E-dictliylnnliiio-.sec.nmylamino-G-metIiosyr~uinolirtc, so that the formula of plasmoquinc base is probably (111).
Thc British Pntcnt 267,169, which claims tlic substance 111 and othcr nminonlkJ.lnminoqiiiiiolincs of similar typo, also clninis substances containing n hydrosy group in tlic sidc chin, for esnmplc, the siibstnncc 1 1 ' . Othcr pntcnts clnim (a) compoiinds of