Some physiological functions of theL-leucine dehydrogenase inBacillus subtilis
✍ Scribed by Norbert Obermeier; Karl Poralla
- Book ID
- 104770022
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 458 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0302-8933
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✦ Synopsis
Mutants of Bacillus subtilis constitutive for L-leucine dehydrogenase synthesis were selected. Using these mutants we could determine two functional roles for the L-leucine dehydrogenase. This enzyme liberates ammonium ions from branched chain amino acids when supplied as the sole nitrogen source. Another function is to synthesize from L-isoleucine, L-leucine, and L-valine the branched chain e-keto acids which are precursors of branched chain fatty acid biosynthesis. These results together with the inducibility of the enzyme suggest that the L-leucine dehydrogenase has primarily a catabolic rather than an anabolic function in the metabolism of Bacillus subtilis.