Some pharmacological properties of polymyxin B sulfate

✍ Scribed by Darrell L. Witt; J. P. Long

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 223 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600531226

✦ Synopsis

with respect to microbiological potency under the conditions studied.

Studies on modifications of the aqueous propylene glycol formulation indicate that pH and propylene glycol content are critical factors. If the propylene glycol content is a t a level of 50% or greater a t pH 8.0-8.5, there is little or no loss of microbiological potency after 9 weeks at 37'. If the pH ranges from 8.0 to 8.5, the formulation retains its potency after 5 weeks a t 37'. Below this pH range, the formulation slowly loses activity, presumably through C.4 epimerization, the kinetics of which have recently been described (4).