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Some pharmacological and toxicological studies on Balanites aegyptiaca bark

✍ Scribed by Dr. A. H. Mohamed; K. E. H. Eltahir; M. B. Ali; M. Galal; I. A. Ayeed; S. I. Adam; O. A. Hamid

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
36 KB
Volume
13
Category
Article
ISSN
0951-418X

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✦ Synopsis

The aqueous extract of Balanites aegyptiaca bark, which is used in Sudanese folk medicine in the treatment of jaundice, was without effect when studied on rabbit intestine, rabbit aortic strip, rat stomach strip, rat uterus and rat phrenic nerve-diaphragm in a dose up to 10 mg/mL gut bath. In a larger dose (25 mg) the extract decreased significantly the contractility and the rate of the isolated perfused rabbit heart. Administration of the aqueous extract to biliary duct-ligated rats, showed a dose-dependent significant decrease in serum bilirubin level. The chronic and subchronic toxicity investigations indicate the safety of the aqueous extract at a dose level which showed a significant decrease in serum bilirubin level in experimental obstructive jaundice in rats.

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