Some developmental observations on the effects of prolonged deprivation of Low-voltage Fast-wave sleep in the deermouse, peromyscus maniculatus Bairdi
✍ Scribed by Merrill M. Mitler
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 1019 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0012-1630
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✦ Synopsis
Mitler, Merrill M. (1971). Some Developmental Observations on the Effects of Prolonged Deprivation o f Low-voltage Fast-wave Sleep in the Deermouse, Peromyscus Maniculatus Bairdi. DEVELOPMENTAL PSYCHOBIOLOGY, 4(4): 293-3 1 1. Previous electrophysiological work with adult deermice (P. m. bairdi) (Mitler & Levine, 1970) indicated that: three states of arousal could be reliably distinguished: low-voltage, fast-wave sleep (LVF), high-voltage, slow-wave sleep (HVS), and waking (W); low-electromyograph (EMG) activity was concomitant with LVF; and time in LVF was radically reduced in mice perched above a shock-grid on a pedestal too small to permit total loss of muscle tonus. A preliminary aim of the present research was to gather electrophysiological data on juvenile deermice to construct some estimate of developmental sleep changes. Electrocorticograph (ECoG) and (EMG) records, from three 20-day-old mice while motionless with eyes closed, also reflected LVF, HVS, and W, but in proportions different from those reported by Mitler and Levine. Juvenile mice showed 1/3 more LVF than did adults. The main goal of this research was to explore the effects of long-term LVF-deprivation on juvenile and adult mice. Litters were selected at either 20 or 53 days of age. Littermates were assigned to one of four 14-day treatment conditions in an Age Treatment design with 3 subjects per cell. The 1st treatment, LVF-deprivation, consisted of perching on a pedestal over a shock-grid. The remaining 3 conditions ran simultaneously with the former. Mice in the yoked control condition had approximately equal free movement volume as those mice restricted to the pedestal, and were 'yoked' to those animals with respect to shock. Mice in the sleep deprivation condition were confined to a treadmill in motion 19 of each 24 hr. Finally, mice in the