Some characteristic features of the biotransport of the cytostatic agent 1,6-dibromo-1,6-dideoxy-dulcitol

✍ Scribed by László Institóris; I. Piroska Horváth; George Pethes

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: French
• Weight: 280 KB
• Volume: 2
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910020105

✦ Synopsis

Aspects of the biological transport of cytostatically active 1,6-dibronio-l,6-dideoxydulcitol ( D B D ) were studied using "Br-labelled material on dogs and Yoshida tuniorbearing rats. Thirty-five per cent of the DBD dose was excreted in the urine within 12 hours. Besides unchanged DBD, metabolites containing C-Br bonds could also be ddected in the urine. In vivo, the 50% decomposition time ojthe C-Br bonds in DBD is about 5 to 6 hours. One hour after administration of DBD, more than SO of the prsisting dose had entered the cells. Accumulation of the drug in the tumor tissue could not be demonstrated. A fraction of the dose enters the enterohepatic circulation.

The cytostatic agent 1,6-dibromo-l,6-dideoxydulcitol (DBD, I in Fig. ) is a diastereomer of the antileukemic drug 1,6-dibromo-l,6-dideoxy-D-mannitol (DBM, Myelobromol@, IT in Fig. ).