Some Basic Derivatives of Pummerer's Ketone
β Scribed by Piero Valenti; Maurizio Recanatini; Maria Magistretti; Paolo Da Re
- Book ID
- 101638017
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 195 KB
- Volume
- 314
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The use of Pummerer's ketone as pharmacophoric synthon is described and a preliminary account of the pharmacological properties of the new derivatives, basic esters, is given.
π SIMILAR VOLUMES
## Abstract ^1^H NMR spectra are reported for Michler's ketone and twenty of its derivatives, along with ^13^C chemical shifts for five of the compounds. ^1^H chemical shifts show only small changes with increasing substitution at the sterically hindered 2βposition. Estimates of the dihedral angle
Acyclic alpha,beta-unsaturated ketones were synthesized and treated with either 2-mercaptoethanol or cystenamine hydrochloride under the simulated physiological conditions. The thiol group of these model biological nucleophiles underwent Michael type addition to the activated double bond. The incuba