T h e neurotoxicity, antielectroshock, anti-Metrazol, and antistrychnine activities of another series of urazole compounds have been determined in mice. Depending upon the nature of the substituted nitrogen groups, the members of this series, as with the previous compounds, were found to possess antielectroshock, anti-Metrazol, antistrychnine, convulsant, and depressant type actions. In general, the urazole compounds are most effective against maximal Metrazol seizures. HE SIMILARITY of the urazole and hydantoin Tnucleus prompted a n investigation of the C. N. S. activity of a series of substituted urazoles. One group of these derivatives has been reported previously (1). The compounds were relatively short acting and nontoxic. In general, they were found t o be most effective against maximal Metrazol seizures. Variations in the substituted nitrogen groups yielded compounds possessing anticonvulsant, convulsant, and depressant type actions. This report concerns the C. N. S. activity of another series of urazole derivatives and some observations concerning the structure-activity relationship of the C. N. S. actions of the entire series.
EXPERIMENTAL
Adult male albino mice obtained from the Arthur Sutter Farms (Rockland strain), weighing 20 to 25 Gm.. were maintained on Purina laboratory chow