The mechanisms of iron accumulation by cultured hepatocytes isolated from fetal rat liver (19 days gestation) were investigated using rat transferrin labeled with ' ' ' 1
Some aspects of iron uptake by rat hepatocytes in suspension
โ Scribed by Dietmar Grohlich; Colin G.D. Morley; Anatoly Bezkorovainy
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 716 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0020-711X
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๐ SIMILAR VOLUMES
HFE-related hereditary hemochromatosis results in hepatic iron overload. Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by th
The apparent kinetics of uptake of various model substrates were examined for hepatocytes in suspension and primary culture up to 72 h. The ability of hepatocytes to take up taurocholate and ouabain was decreased in culture. Vmax for uptake of both substrates diminished rapidly with increasing time
## Background: While phagocytosis by kupffer cells (stellate perisinusoidal macrophages) is well known and that by endothelial cells also is thought to occur under certain conditions, the uptake of large particles by hepatocytes has not been well studied. we reported previously the selective phagoc