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Somatically acquired genetic alterations in flat colorectal neoplasias. Int. J. Cancer77, 366–369 (1998).

✍ Scribed by S. Olschwang; P. Slezak; M. Roze; E. Jaramillo; H. Nakano; K. Koizumi; C. A. Rubio; P. Laurent-Puig; G. Thomas

Publisher: John Wiley and Sons
Year: 1998
Tongue: French
Weight: 33 KB
Volume: 78
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19981029)78:3<396::aid-ijc26>3.0.co;2-3

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Somatically acquired genetic alterations

Somatically acquired genetic alterations in flat colorectal neoplasias

✍ Sylviane Olschwang; Premysl Slezak; Maud Roze; Edgar Jaramillo; Hiroshi Nakano; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 385 KB 👁 1 views

Somatically acquired mutations in several genes have been reported as playing an important role during colorectal tumorigenesis. Two alternative groups of carcinomas, termed LOH+ and RER+, have been defined on the basis of their genetic anomalies, a biallelic inactivation of the APC or the TGF-betaR