Somatic overgrowth associated with overexpression of insulin–like growth factor II
✍ Scribed by Morison, Ian M.; Becroft, David M.; Taniguchi, Takanobu; Woods, C. Geoffrey; Reeve, Anthony E.
- Book ID
- 109927657
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 803 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1078-8956
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## Abstract Insulin‐like growth factor‐I (IGF‐I) is widely expressed in the central nervous system (CNS). Whereas during normal development IGF‐I is expressed predominately by neurons and to a much lesser degree by glial cells, its expression in astrocytes, and often in microglia, is increased duri
Insulin-like growth factor I1 is believed to play an important role in fetal growth and development. The insulin-like growth factor I1 gene expression is tissue specific and developmentally regulated. We have previously shown an enhanced level of insulin-like growth factor I1 messenger RNA and prote