Somatic mutations in VNTR-Locus D1S7 in human colorectal carcinomas are associated with microsatellite instability

There is no increase in frequency of som

There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability

✍ Rebecca Barnetson; Robert Eckstein; Bruce Robinson; Margaret Schnitzler 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

## Abstract This study investigates the molecular features of metastasis in sporadic colon carcinomas with high‐level microsatellite instability (MSI‐H). DNA from 51 regions from 10 MSI‐H metastatic carcinomas and 26 corresponding metastases was analyzed for mutations in __TGFBRII__, __IGFIIR__, __