Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers
✍ Scribed by Xiang Jiao; Laura D. Wood; Monica Lindman; Sian Jones; Phillip Buckhaults; Kornelia Polyak; Saraswati Sukumar; Hannah Carter; Dewey Kim; Rachel Karchin; Tobias Sjöblom
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 967 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Abstract
Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF‐KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved. © 2012 Wiley Periodicals, Inc.