Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it
β¦ LIBER β¦
Somatic mutations affect key pathways in lung adenocarcinoma
β Scribed by Ding, Li; Getz, Gad; Wheeler, David A.; Mardis, Elaine R.; McLellan, Michael D.; Cibulskis, Kristian; Sougnez, Carrie; Greulich, Heidi; Muzny, Donna M.; Morgan, Margaret B.
- Book ID
- 109897802
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 566 KB
- Volume
- 455
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Lung adenocarcinomas often metastasize to the brain, and the prognosis of patients with brain metastases is still very poor. The __epidermal growth factor receptor__ (__EGFR__) gene is mutated in a considerable fraction of primary lung adenocarcinomas, in particular those with drastic r
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