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Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability

โœ Scribed by Ma, Ai-Hong; Xia, Liang; Littman, Susan J; Swinler, Sandra; Lader, Gabriel; Polinkovsky, Alexander; Olechnowicz, Joseph; Kasturi, Lakshmi; Lutterbaugh, James; Modrich, Paul


Book ID
110062897
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
195 KB
Volume
19
Category
Article
ISSN
0950-9232

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Aberrant splicing of the ATM gene associ
โœ Yosuke Ejima; Lichun Yang; Masao S. Sasaki ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 181 KB ๐Ÿ‘ 2 views

Inherited mutations of the ATM gene are responsible for the human autosomal recessive disorder ataxia-telangiectasia (A-T) characterized by pleiotropic clinical manifestations. ATM mutations are also involved in the development of sporadic human cancers such as T-cell prolymphocytic leukemia and B-c