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Somatic insertions and deletions shape the human antibody repertoire

✍ Scribed by Ruud M.T de Wildt; Walther J van Venrooij; Greg Winter; René M.A Hoet; Ian M Tomlinson

Book ID
115629806
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
328 KB
Volume
294
Category
Article
ISSN
0022-2836

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Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m