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Somatic Hypermutation and B Cell Receptor Selection in Normal and Transformed Human B Cells

✍ Scribed by RALF KÜPPERS


Book ID
111398006
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
198 KB
Volume
987
Category
Article
ISSN
0890-6564

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During a follicle centre response, the immunoglobulin genes are subjected to a hypermutation mechanism which introduces predominantly single base changes, non-randomly, into the immunoglobulin V region (IgV) genes. B cells with mutated IgV genes are then selected according to the affinity of the enc