Somatic hypermutation and B-cell maligna
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Spencer, Jo; Dunn-Walters, Deborah K.
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Article
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1999
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John Wiley and Sons
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English
⚖ 223 KB
During a follicle centre response, the immunoglobulin genes are subjected to a hypermutation mechanism which introduces predominantly single base changes, non-randomly, into the immunoglobulin V region (IgV) genes. B cells with mutated IgV genes are then selected according to the affinity of the enc