𝔖 Bobbio Scriptorium
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Somatic hypermutation and affinity maturation


Book ID
103583939
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
127 KB
Volume
14
Category
Article
ISSN
0167-5699

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Somatic hypermutation and B-cell maligna
✍ Spencer, Jo; Dunn-Walters, Deborah K. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 223 KB

During a follicle centre response, the immunoglobulin genes are subjected to a hypermutation mechanism which introduces predominantly single base changes, non-randomly, into the immunoglobulin V region (IgV) genes. B cells with mutated IgV genes are then selected according to the affinity of the enc