The key immunological event in the pathogenesis of the autoimmune liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains unclear. Mice exposed to self-PDC mount no immune re
Somatic diversification of B cells: a role for autoreactive T lymphocytes
โ Scribed by Ronald B Corley
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 359 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
B-cell antigen receptor (BCR) signals are crucial for initiation of humoral immune responses and must be actively modulated and/or terminated in preparation for receipt of subsequent cues for progression. BCR signaling is also actively inhibited in autoreactive cells in which unresponsiveness is mai
## Abstract Resident T lymphocytes have been found to exert helper and suppressor regulatory influences with regard to polyclonal activation of murine splenic B lymphocytes elicited by lipopolysaccharide. In the normal adult spleen, only T cell helper influences are exercised over polyclonal B cell